Share Posted by << Previous PostNext Post >> TORONTO — When Philip Rose took over as Regional Director, Canada for the Jamaica Tourist Board seven years ago, he came here from the U.S. “and I had all my big ideas. I quickly learned that Canada is a very unique market with nuances that cannot be overlooked.”Rose is leaving the JTB’s Canadian office for a new post with the tourism board, an appointment he says he’ll be able to announce in the next couple of weeks. He starts his new role in the new year, and meanwhile a new Regional Director will be announced for the Canadian market.Does Rose have any advice for the incoming new Regional Director? “Ask questions. Listen. Trust the team. And trust the partners,” he says.Asked what he’s most proud of, looking back on his 7 years heading up the Canadian market, Rose singles out his Canadian team: “I’m especially proud of how active, how professional my team has been here.” And, he adds, he’s proud of all the extra airlift to Jamaica.When Rose took over the post seven years ago, the Canadian dollar was starting to decline after a run at-par, prices to Jamaica had gone up and capacity had gone down. “It was like ‘Welcome to Canada, Philip’,” he jokes.More news: Onex paying big to get WestJet and that will send airfares soaring, says CWT“All of our partners rallied together and went to the market and our numbers started to rise.”Over the 7 years, “we’ve done remarkably well,” says Rose.More importantly than the increase in visitor numbers from the Canadian market, Rose and his JTB have also put in place new strategies that will ensure ongoing visitor satisfaction levels with the Jamaica travel experience remain high, and return rates stay high as well. “We’re not only interested in the numbers increasing from Canada, but also customer satisfaction,” he says.He adds: “We firmly believe one of the reasons for our high return rate is that we take the time and invest the resources to ensure our retail partners have the tools to make sure their clients are in the resort that’s right for them.”Rose says he wants to thank everyone in the industry for all the support over the years. “I have made some incredible friends here, both in the industry and in the community. I will miss you all! Canada has been good not only to me, but to my family too. We have been proud to call Canada home for seven wonderful years, and we are truly going to miss it…other than the Toronto traffic and winters, of course,” he jokes.More news: Consolidation in the cruise industry as PONANT set to acquire Paul Gauguin CruisesRose officially ends his stint as Regional Director, Canada for the JTB on Dec. 15 – “just before the brutally cold temperatures”.Seven years ago Rose arrived in Canada from Texas, where he was in charge of the Western USA market. Is he headed back to the U.S. in his new JTB role? Time will tell but if it’s another cold climate, he’ll be well-prepared, thanks to the lessons he learned here in Canada: “I now wear a toque as opposed to a hat.” Monday, December 3, 2018 Travelweek Group JTB’s Philip Rose says ‘until next time’ as he leaves Canadian market after 7 years Tags: Departures, Jamaica, JTB
“You put a high motor with a 4.46 guy at that size, just inside rush, outside rush, he destroyed those guys at the Senior Bowl in the one-on-one pass rushes,” Arians offered. “What impressed me more was he’d never done it, but he went and covered the backs one-on-one and nobody caught a pass on him and he’d never done it. That’s when you knew you had something real special.”Reddick, who was already a top prospect even after playing at Temple, did nothing to hurt his stock in Mobile, AL.“At the Senior Bowl, he stepped in with all the top talent and played different positions and dominated,” Keim added.Reddick himself understands how much his Senior Bowl performance helped his stock, but interestingly, it almost never happened. Sort of.Phil Savage, the executive director of the Senior Bowl, told Burns and Gambo on 98.7 FM, Arizona’s Sports Station that back in October he had a conversation with Reddick’s coach at the time, Matt Rhule, and asked if the coach felt his player could switch to linebacker from the defensive end position he played at Temple.It may have been a tough ask, especially since last season Reddick notched 65 tackles with 10.5 sacks and an FBS-leading 22.5 tackles for loss. He also forced three fumbles and recovered one fumble while recording an interception. Not long after choosing Haason Reddick with the 13th overall pick in the 2017 NFL Draft, Arizona Cardinals GM Steve Keim and head coach Bruce Arians talked about how his performance at the Senior Bowl really stuck in their minds.“He went to the Senior Bowl as I talked about in the pre-draft press conference,” Keim said. “I’ve never seen a guy who could take his hand off the ground and play stack linebacker with that kind of vision, instincts and play speed, and coverability, like he did with very little experience.” LISTEN: Phil Savage, Executive Director of the Senior Bowl The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo 0 Comments Share Rhule thought he could make the move, noting he felt linebacker would be Reddick’s position in the NFL, so Savage and the Senior Bowl invited the player to participate in the event, but as a linebacker.“About two weeks before he was supposed to get here, his agent called and said, ‘Hey, he’s having some reservations about playing linebacker in Mobile,’” Savage said. “I said, ‘Let me talk to him when he gets here.’”So, on the Sunday before practices started in late January, Savage encouraged Reddick to give linebacker a shot, ensuring him he would show the kind of versatility that would help him.“By the end of the week he was probably moved from being a third-rounder, in terms of a conservative guess across the league to the back end of the first round,” Savage said. “Once he followed up our week with the Combine, the measurables, the interview, the personality, and he just kept skyrocketing up the draft board through the spring.”Indeed, Reddick also helped himself at the Combine with a 4.52 second 40-yard dash time as well as a 36.5-inch vertical jump and 133-inch broad jump.But as Savage noted, no one helped themselves more at the Senior Bowl than Reddick, who used the week to show the kind of athleticism and versatility that attracted the Cardinals. Former Cardinals kicker Phil Dawson retires Yet, while Williams was incredibly productive in college, he made it to the Senior Bowl because, as Savage said, he received a tip on the wideout.“I had one of my contacts go to Itawamba, Mississippi, to see Grambling play Mississippi Valley State,” Savage said. “And so our scout, he calls me in the middle of the night on a Saturday night during the season, says, ‘Hey, this receiver at Grambling’s legit, he’s got size and I think he’s going to run well enough.’“That was the knock on Chad Williams during the fall is maybe he didn’t run fast enough because it’s hard to gauge sometimes when you’re looking at a small-college prospect.”Savage says they ultimately decided to extend an invitation to Williams, and from the very first practice showed he was competitive and tough.“He was stronger and more physical and faster than maybe people anticipated, and I was honestly shocked when he wasn’t invited to the Combine,” Savage said. “I thought it was a no-brainer.”Savage went on to say once Williams excelled at his pro day, in which he was timed at 4.37 seconds in the 40, being drafted was definitely in his future. “I thought he would probably be a fourth or fifth-round choice, but the Cardinals jumped in there in the third round and took Chad,” he said. “He’s a very competitive, physical-type of player.“He got in a couple of fisticuffs down here because he wanted people to notice him, I think, with the defensive backs. I like Chad a lot and I’m very hopeful that, if given time, he can really develop now with some bonafide pro coaching and being in the pro weight room and being around other professional receivers. He’s got a chance to really develop.” When it comes to evaluating players, teams look for as much information as possible. Savage said the Senior Bowl allows coaches and scouts to get an early look at prospects from all over the country and therefore have an idea of what the upcoming draft holds.“So that they can make those comparisons, because that’s really what you’re doing in scouting, you’re comparison shopping from small-school guys all the way up to the big-school All-Americans and trying to make some choices based on that information,” he said.Reddick, however, was likely going to be a pretty high pick even without his outstanding Senior Bowl week. Another player the Cardinals chose, receiver Chad Williams, probably could not say the same.The Cardinals plucked Williams out of Grambling State in the third round, 98th overall, and like Reddick, mentioned what he did in Mobile.“This is a bigger, more physical, explosive, fast receiver and when he went to the NFLPA (Collegiate Bowl) he did extremely well, got invited to the Senior Bowl, was not out of place; if anything, he dominated all of the one-on-ones,” Arians said.As a senior, Williams caught 90 passes for 1,337 yards and 11 touchdowns, and in his career totaled 210 receptions, 3,062 yards and 28 scores. Top Stories Derrick Hall satisfied with D-backs’ buying and selling Your browser does not support the audio element. North squad inside linebacker Haason Reddick of Temple (57) practices for Saturday’s Senior Bowl college football game in Mobile, Ala., Wednesday, Jan. 25, 2017. (AP Photo/Brynn Anderson) Grace expects Greinke trade to have emotional impact
14Mar House approves Griffin’s bill to give schools financial flexibility for facility improvements Categories: Featured news,Griffin News,News The Michigan House of Representatives today approved Rep. Beth Griffin’s legislation to allow school districts to make energy efficiency and operational upgrades to school facilities by entering into a lease-purchase agreement.The bill will provide another financing option for schools to achieve savings through energy efficiency and operational improvement projects.“Conservation projects that qualify are improvements to local school buildings that reduce energy consumption such as heating and cooling upgrades or the installation of more efficient lighting,” said Rep. Griffin, of Mattawan.Operational improvements to phones and technological updates are included in the conservation projects as well.Griffin, who is also a former schoolteacher, said that a lease-purchase agreement is not considered a debt, which allows school districts to fund projects that may have not been within budget.“This will afford school districts the opportunity to save money on much needed infrastructural improvements and redirect funding to classrooms to help our teachers and students excel,” said Griffin.House Bill 4080 will now move to the Senate for consideration.###### Tags: #SB
Romanian cable and pay TV operator RCS & RDS has completed tests of 100GbE technology, the first such test in the country.RCS & RDS tested 100GbE with DWDM equipment for ECI Telecom and routers from Cisco and Juniper. RCS & RDS said this was the first test globally involving three separate vendors.The operator tested 100GbE IP/MPLS equipment over a 700km distance between Bucharest and Oradea. Upgrading networks from 10GbE to 100GbE increases capacity by a factor of 10, allowing service providers to serve a much larger number of customers with high-bandwidth services simultaneously.
Polsat Group founder Zygmunt Solorz-Zak has resigned from the supervisory board of the company to take a back-seat strategy role.Solorz-Zak’s son Tobias is already president of the group, and Solorz-Zak Sr.’s decision to step down from the board is being seen by Polish media as possibly part of a succession plan.Polsat has named Tomasz Szeląg and Marek Kapuscinski as new members of the supervisory board. Szeląg has held a number of senior positions in the group, having served as a member of the management board as well as the management board of Polkomtel and Telewizja Polsat Holdings. Kapucinski previously spearheaded Proctor & Gamble’s activities in Poland and central Europe.Szeląg’s appointment was trailed in August as part of a series of changes at Polsat.
In This Issue… * The dollar loosens it grip * Jobs market continued to improve * Investors testing Norges * A rate hike in the cards And, Now, Today’s Pfennig For Your Thoughts! Clear as mud… Good day…and a Fabulous Friday to one and all. This will take care of my call from the bullpen for now, so Chris will have the ball for the next couple of weeks until Chuck returns at the end of the month. The summer time heat finally loosened its grip on St. Louis yesterday and the dollar strength which had a tight hold in the markets earlier in the week saw some pullback. We didn’t see much action in the overnight markets Thursday morning so everything was fairly flat when I sat down at my desk. The dollar buying frenzy did subside, but we didn’t see a total reversal that would offset the damage from Tuesday and Wednesday. I guess you could say the US dollar party got a warning for being a little too loud but it hasn’t gotten broken up just yet. I think the novelty of the Fed statements have started to wear away and investors are looking for more confirmation that QE3 really has been relegated back to the basement and additional data before they go much further. That’s not to say we could see some safe haven buying here and there, but I think it would be a while before the Fed could officially rule out additional stimulus measures. With that being said, we could see more emphasis placed on the US economic reports over the next couple of months as investors try and gauge where things actually stand, with the caveat that problems in Europe don’t flare up. While data has seen improvement in certain areas, there hasn’t been enough, in my opinion, to demonstrate the economy has the traction to carry on without the safety net of government stimulus. We did have several reports to talk about from yesterday morning, so let’s jump right in. Starting with the producer price index, wholesale inflation, the annualized figure did fall, as expected, in February to 3.3%, from the previous reading of 4.1%, and marked the slowest year over year gain since 2010. We saw the same thing with the cost of imported goods as the annual figure dropped lower, however, the monthly figure for both PPI and the import index gave us much higher readings than the previous reports. In fact, wholesale prices rose 0.4% from January and reflected the highest increase in five months. The Labor Department prints three monthly inflation reports, two of which we’ve already seen, so today we see the final gauge of inflation for February through the consumer price index. The CPI numbers are expected to fall in line with the other reports by showing no year over year inflation but is expected to show a monthly increase. The headline CPI number is expected to rise 0.4% in February, but core inflation is forecast to remain flat. The only problem with the core calculation is that both food and energy are taken out of the equation, which happens to be the two most frequently used consumer products. When the Fed stated oil will push up inflation temporarily, it’ll be interesting to see just how temporary this scenario plays out, especially if demand really does pick up. Moving over to the employment side of things, the jobs environment demonstrated another week of a step in the right direction as initial jobless claims fell to 351k, the lowest level in four years, from last week’s upward revision to 365k. The four week moving average, which is typically a less volatile figure, held firm at just under 356k. The number of people collecting unemployment benefits, which doesn’t include extended benefits, decreased to 3.34 million. With employment continuing to head in the right direction, the Bloomberg consumer comfort report yielded the highest level since March 2008. The equity markets have been on the rise over the past several months, so seeing positive returns on those portfolio statements also goes a long way in making someone feel a little better. The U. of Michigan confidence report will be released this morning so I’m sure we’ll see another pickup in the happy factor. The TIC flows, which measures international demand for longer term US financial instruments, surged in January to $101 billion. The markets used to pay attention and actually consider this a must see report, but the Fed pretty much threw water all over it when they kicked the printing presses into high gear. Anyway, thoughts of whether Greece would default or get another bailout spurred the safe haven movement into US Treasuries so that pretty much explains the rise. Other than that, nothing new as China and Japan still own over $2 trillion worth of Treasuries combined. Rounding out the remaining data reports from yesterday, the regional manufacturing figures both increased to multi-month highs and points to a rise in the national report, the ISM, which is due on April 2. The other reports that I haven’t touched on include industrial production and capacity utilization. If the secondary manufacturing reports and other indications hold true, we should see improvement in both figures. Looking ahead to next week, it’s shaping up to be a fairly slow week in the data department as it will pretty much be dominated by February housing numbers. As I mentioned earlier, the US dollar lost ground yesterday even though we had some positive economic numbers that could have kept the rally going. It looks like investors were willing to again venture out into the riskier asset arena as equities rose along with the major currencies. The trend that’s been in place for quite some time, which consists of positive US or global economic news promotes a weaker dollar, was back in the ring. I’m sure some of the cheaper prices, namely in gold and silver, enticed investors to get off the couch. The New Zealand dollar topped the charts by turning in a nearly 1.25% performance. An increase in February manufacturing to almost a two year high gave the kiwi an extra shot and gave investors a reason to pick up the currency at a seven week low. We’re starting to see better economic data coming out of New Zealand, but the much larger economy from Australia often casts a shadow they can’t escape. The Swiss franc remained near the top of the currency returns leader board yesterday by gaining just over 1%. The SNB, Swiss National Bank, met yesterday and kept interest rates on hold as expected. There wasn’t any earth shattering news surrounding the meeting, but they did express a more upbeat attitude regarding the economy. The SNB raised its growth forecast for this year by predicting GDP will rise 0.8%, instead of the previous estimate of 0.5%, and pushed away the prospects of a recession. The SNB also reiterated they will defend the 1.20 per euro ceiling that was established in September with the utmost determination. They don’t want to appear overly optimistic and attract too much attention, so continuing to fly under the radar is where policy makers would like to stay. While 4th quarter GDP and investor confidence has risen recently, the central bank is still concerned about deflation derailing the recent economic stabilization. One of the statements from the SNB explained that while the high value of the franc continues to present enormous challenges to the economy, the minimum exchange rate is having an impact. They went on to say the ceiling has reduced the extreme exchange rate volatility and has given business leaders a better basis for planning. In the end, any currency appreciation will be met with government intervention and economic policy changes look to be a long ways down the road, so there’s no reason to spend much time here in the foreseeable future. The Norwegian krone, interestingly enough, finished in the top five after its dismal performance on Wednesday. They did report a record trade surplus in February as rising oil prices boosted exports, but it looks as though speculators were trying to crack the code as the government’s pain threshold on currency gains. The central bank indicated after the rate cut on Wednesday they intend on keeping rates on hold for the rest of the year unless justified otherwise. Policy makers indicated on Wednesday they don’t defend a specific krone level and that interest rate policy will only respond to the extent that the exchange rate affects the inflation outlook. Most of the currencies had solid returns yesterday anyway so I’m not so sure that speculators trying to break the central bank’s resolve was the prime player. Nonetheless, these were some of the news headlines floating around yesterday and had some investors thinking about another Swiss type of situation. The Canadian dollar didn’t have the same returns as New Zealand or Norway, but it did remain in positive territory and got close to breaking back into the $1.01 handle. On the data side of the table, existing home sales in February rose 1.4% and the average home price climbed 2%. We also saw a Canadian consumer confidence poll rise to its highest level in a year. The higher oil prices and positive US data are starting to feed through to the Canadian economy, not to mention two fundamental pillars of strength which include a commodity based economy and a healthy fiscal position. As I was sifting through the news last night, I saw a story that traders now have over a 50% chance that we could see a rate hike by year end. That scenario might be a stretch given the Bank of Canada likes to follow in the Fed’s footsteps when it comes to rate decisions, but just seeing that thought kicked around says a lot about the Canadian economy. Gold and silver saw some renewed life yesterday as they both traded up around 1% throughout the day. Since they have gotten beat up this week, it looks like the buying on dips crowd were stirring around and scooped up the metals at cheaper prices. I also saw where physical gold demand from India yesterday was the highest level since January of last year, so I’m sure that helped as well. As I came in this morning, the overnight markets didn’t really give us any solid direction as everything traded in a fairly tight range. If anything, the dollar has strengthened this morning but nothing to write home about. There weren’t any global economic reports that held any market moving weight, but we did see a measure of European exports rise for a third month in January. If we look back to December and January, the euro was under some selling pressure from the Greek related anxieties so I’m sure that went a long way helping exporters with a cheaper euro. Then there was this… Evidence of a global economic recovery is real, but the level of optimism it has created deserves skepticism, according to The Economist. Growth is likely to be slower this year than last. In the U.S., stimulus should focus on higher wages, affordable housing, increased health care spending, and pensions. “If policymakers get it wrong again, the recovery could yet turn to dust,” the magazine notes. To recap…The dollar couldn’t keep the party going as most of the major currencies appreciated throughout the day. Consumer confidence displayed another rise as the labor market continues to show life. We saw another drop in the initial jobless claims figure and regional manufacturing reports continue to show improvement. The New Zealand dollar rose against the dollar as domestic manufacturing increased to a two year high and the SNB kept rates on hold while reiterating their commitment to the currency ceiling. The Norwegian krone appreciated despite Wednesday’s rate cut and the odds of a rate hike in Canada increased to over 50%. Currencies today. American Style: A$ $1.0529, kiwi .8184, C$ $1.0064, euro 1.3053, sterling 1.5728, Swiss $1.0811, . European Style: rand 7.6424, krone 5.7910, SEK 6.8088, forint 223.79, zloty 3.1641, koruna 18.8008, RUB 29.40, yen 83.72, sing 1.2623, HKD 7.7636, INR 50.3025, China 6.3229, pesos 12.6874, BRL 1.7983, Dollar Index 80.37, Oil $105.20, 10-year 2.31%, Silver $32.42, and Gold. $1,648.18 That’s it for today…I’ll be glued to the tv this weekend with all of the college basketball games, but my focus will be centered this afternoon when the Missouri Tigers hit the court. We also have St. Patrick’s Day this weekend so top o’ the morning to all that have Irish heritage. I have some Irish blood, so maybe I’ll enjoy a green beverage or two on Saturday, but you wouldn’t guess it be looking at me. You would probably think my holiday of choice would be Columbus Day as my Italian features are fairly prominent. Since I have both nationalities running through my veins, I guess I’m set either way. That’s it for me today and Chris will be back in the saddle on Monday, so until next time…Have a Great Day!! Mike Meyer Assistant Vice President EverBank World Markets 1-800-926-4922 1-314-647-3837 www.everbank.com
(Click on image to enlarge) The Comex Daily Delivery Report showed that 99 gold and 243 silver contracts were posted for delivery on Tuesday within the Comex-approved depositories. In gold, it was ‘all the usual suspects’. In silver, the two big short/issuers were JPMorgan Chase and ABN Amro with 120 and 111 contracts respectively. The biggest long/stoppers were Canada’s own Bank of Nova Scotia with 168 contracts…and then JPMorgan Chase with 59 contracts. The link to yesterday’s Issuers and Stoppers Report is here. There were no reported changes in GLD yesterday but, once again, the big surprise came from SLV, where an authorized participant added 1,691,162 troy ounces of silver…and is virtually the same size of deposit that was made into SLV on Thursday…almost to the ounce, so I’m wondering if this was an double entry error. We’ll find out for sure on Monday if/when they revise their number. Over at Switzerland’s Zürcher Kantonalbank for the period ending March 21st…they reported that their gold ETF declined by a tiny 8,017 troy ounces…and their silver ETF declined by 200,557 troy ounces during the same period. The U.S. Mint had a smallish report. They sold only 500 ounces of gold eagles…along with 1,000 one-ounce 24K gold buffaloes. Month-to-date the mint has sold 45,500 ounces of gold eagles…10,000 one-ounce 24K gold buffaloes…and 2,438,000 silver eagles. Based on these numbers, the silver/gold sales ratio for the month so far is a hair under 44 to 1…which is pretty amazing…and I hope you’re getting your share. Over at the Comex-approved depositories on Thursday, they reported receiving 945,922 troy ounces of silver…and shipped 369,222 troy ounces of the stuff out the door. The link to that activity is here. The Commitment of Traders Report was a surprise. Silver showed a big improvement in the Commercial net short position…and gold showed a big deterioration in its Commercial net short position. In silver, the Commercial net short position declined by 14.9 million ounces…and as of the Tuesday cut-off stands at 132.2 million ounces. Once the market-neutral spread trades are subtracted out of the total open interest, the Big 4 traders are short 38.8% of the entire Comex silver market on a ‘net’ basis. The ‘5 through 8’ traders are short an additional 11.6 percentage points on a net basis. Add them up and the Big 8 are short 50.4% of the entire Comex silver market…and that’s a minimum percentage. In gold, the Commercial net short position increased by a whopping 2.02 million ounces…blowing out to 16.24 million ounces. But the ‘good’ news, as Ted Butler pointed out to me on the phone yesterday, was that there was no increase in the short position of the ‘Big 8’ traders…which includes the BIG 3…JPMorgan, Canada’s Bank of Nova Scotia…and HSBC USA. All of the increase was the result of the smaller Commercial traders selling some of their long positions for a profit. On a ‘net’ basis the Big 4 traders Commercial traders are short 25.4% of the entire Comex gold market…and the ‘5 through 8’ traders are short an additional 13.7 percentage points of the gold market. So the Big 8 are short 39.1% of the entire Comex gold market on a ‘net’ basis. In terms of troy ounces held short, the Big 8 are short 13.97 million ounces of gold…which represents 86.0% of the Commercial net short position in that metal. In silver, the Big 8 are short 264.4 million ounces…and that amount of silver represents 200.0% of the Commercial net short position. Looking at the numbers in the previous paragraph it’s easy to see that, compared to silver, gold appears to be almost a free market…which it isn’t, as the gold market is also rigged seven ways to heaven. Here’s Nick Laird’s incomparable “Days of World Production to Cover Comex Short Positions” chart as of the March 19th cut-off. Silver opened virtually on its high of the day at the beginning of Far East trading on Friday…and was down about twenty cents to the $29 spot price just minutes before 8:30 a.m. in New York. Less than ten minutes later, the price had cratered by about 40 cents…and from there, the price pattern was almost identical to gold’s, with the only minor difference being the fact that the absolute low tick [$28.45 spot] came on a quick spike down at 12:15 p.m. Eastern time. Silver closed at $28.76 spot…down 42 cents from Thursday. Gross volume was pretty decent at around 42,500 contracts. Despite the fact that gold got smacked pretty good earlier in the day, the gold stocks rallied into positive territory by shortly after 10:00 a.m. in New York. Then, shortly after that, someone came along and sold the gold stocks off a percent…with the low of the day coming around 11:30 a.m. Eastern time. From that point, the stocks rallied back slowly, and the HUI finished down 0.73%. Needless to say, the silver stocks didn’t exactly shine yesterday…as virtually all of them finished in the red. But they did follow almost the same price path as the gold stocks. Nick Laird’s Intraday Silver Seven Index closed down 1.17%. (Click on image to enlarge) Here’s a series of three photos that my daughter Kathleen sent me yesterday. What is it with cats and boxes? And it obviously doesn’t matter about the size of the cat…domestic or otherwise! (Click on image to enlarge) Here’s Nick’s Silver Seven index which shows the longer term. With the obvious exception of the first story, it’s pretty much wall-to-wall stories about Cyprus for you today….and they’re mostly presented in the order I received them yesterday. These stories seem to change by the hour…and it will be interesting to see how this all turns out. There are no market anymore…only interventions. – Chris Powell, GATA Today’s pop ‘blast from the past’ takes me back to my last year in high school in 1966. This ‘Go-Go’ tune got seemingly endless air time when it was first released…and it’s still a classic to this day. The group was basically a one-hit wonder…but what a hit it was! It’s old enough that the youtube.com video clip is in black in white. I hope you enjoy it…and the link is here. Today’s classical selection is a tone poem by Finnish composer Jean Sibelius. The Swan of Tuonela was originally composed in 1893 as the prelude to a projected opera called The Building of the Boat. Sibelius revised it two years later as the second of the four sections of the Lemminkäinen Suite (Lemminkäis-sarja), also known as the Four Legends from the Kalevala, Op. 22, which was premiered in 1896. Sibelius revised the tone poem twice, once in 1897 and again in 1900. Here’s the Norwegian Radio Orchestra under the baton of Avi Ostrowsky. This recording is as good as it gets…as is the divine playing of the cor angl’e soloist. The link is here. Enjoy. Well, it was another case of JPMorgan et al moving the markets because they could…not because there were any fundamental changes in supply and demand in both gold and silver. If you take a quick peek at platinum and palladium, their chart patterns were unscathed yesterday. As I mentioned earlier this week, “da boyz” can move these market any which way they want…as there are no adults in charge anymore…either at the CFTC or in the mining companies. Gold seems to have topped out just above the $1,600 price mark for the moment…and silver is safely back under the $29 spot price mark. Where these markets go from here is unknown, but whatever direction we go in, will have nothing to do with real supply and demand fundamentals. That’s all I have for today. As I mentioned at the top of this column, I’ll be out of town for a large portion of next week…and I can absolutely guarantee that the columns I post while gone, will be much shorter. I await the Sunday night opening in New York with some degree of interest. As I mentioned earlier this week, “da boyz” can move these market any which way they want NOTE: I will be on the road most of next week…and will be writing my column on my laptop, which is an ordeal that I put myself through as few times a year as possible. They will also be as short as I can make them…and the ‘Critical Reads’ section will shrink alarmingly during this time period. The gold price didn’t do a lot for most of the trading day in the Far East on Friday, but starting around 3:00 p.m. Hong Kong time, the price developed a negative bias…and shortly before 1:00 p.m. in London, the decline began more severe. About forty minutes later…shortly after 8:30 a.m. in New York, it had hit its low tick of the day, which Kitco reported as $1,602.80 spot. The subsequent rally lasted until 10:15…and the price sagged a bit from there until shortly before 2:00 p.m. Eastern. The gold price gained a couple of dollars from there going into the 5:15 p.m. electronic close. In actual fact, it was all a tempest in a teapot, as volume was very light once again yesterday…around 84,000 contracts net, the same as Thursday’s volume. The gold price closed at $1,609.20 spot…down $5.60 on the day. I couldn’t help but notice that Friday’s silver price path was almost a mirror image of the Thursday price pattern, which is hardly a coincidence I would think. The dollar index opened at 82.86 in early Far East trading on their Friday morning…and more or less traded flat until shortly after 8:30 a.m. in London. From there it rolled over a hair…and headed south. The absolute low tick came moments before noon in New York…and then didn’t do much after that…closing the day at 82.37…down 49 basis points from the Thursday close. Once again there was absolutely no correlation between what the dollar index was doing…and what was going on in the Comex paper markets in gold and silver. Sponsor Advertisement 2013 – A Breakout Year for Energy? The energy sector is a volatile market, but it can provide enormous gains to investors who know what they’re doing – and now is the time to get into the two most promising energy trends for 2013 and beyond. Top energy analyst Marin Katusa tells you what you should be bullish and bearish on this year in his special report, The 2013 Energy Forecast. Read it here for free.
User-led and disabled people’s organisations hold the key to fighting back against the government’s long-term assault on the welfare state, according to a leading disabled academic.In his new book, All Our Welfare: Towards Participatory Social Policy, Professor Peter Beresford argues that service-user and disabled people’s organisations (DPOs) “offer a force for achieving change” and for moving towards a “future sustainable welfare state”.Beresford (pictured), who chairs Shaping Our Lives, the national network of disabled people and service users, says in his book that the new identity movements of the 1970s – such as the disabled people’s movement – developed new ways of thinking.They offered new ideas and models of support, and more equal methods of research; and they developed co-operatives, and focused on environmental sustainability and the importance of meeting people’s needs and rights.But faced with a dominant right-wing media and politics, they survived only as an “undercurrent”.Now, he says, the disabled people’s movement, which overcame “massive struggles” to develop its own pioneering, user-led services, can provide the foundation for a new “revisioned” welfare state, pushing back against the current media and political forces that want to marginalise the idea of welfare.“I don’t see any other progressive way forward,” he told Disability News Service (DNS). “If we don’t manage to have that then I fear for where this country will be heading.”He believes that successive governments have performed a “conjuring trick”, by transforming the welfare state – which historically has included services such as the NHS, social care, education and social housing – to simply mean welfare benefits.“The welfare state, according to this government, is now ‘welfare’,” he says, “which means ‘people getting benefits that you are paying for, who are scum.’ That’s how they are presenting it.”But Beresford, who is professor of citizen participation at the University of Essex and emeritus professor at Brunel University, is convinced that the seeds of the downfall of the government’s right-wing, anti-welfare state approach have already been sown.“It’s difficult to be optimistic in terms of how many terrible things are going to continue to happen,” he told DNS, “but I don’t see it is a sustainable road of travel in where we are headed, I really don’t.”He believes that younger people will feel more and more beleaguered by the prospect of huge higher education debts, and having to find the money to cope with job insecurity and – if the welfare state continues to be whittled away – healthcare, pensions and social care.Young families with disabled children “will not tolerate what people tolerated 20, 30, 50 years ago; they want a life for their children; they see their children as like anybody else”.And older people, he says, now worry about their grandchildren, and where their jobs will come from, and where they will live.He believes these factors will provide a “growing groundswell that will be encouraging for the radical movements like the disabled people’s movement”.“The concerns are rising,” he says. “My concern is how long it will take, how much damage will be done in the meantime.”Beresford believes that the most important question is “how we look after each other in modern society”.“This government has pretended that we can do that on our own and that really the issue is all these people claiming rights and income they are not entitled to.”But he does not advocate a return to the “old paternalism” of the post-war welfare state, which “failed to involve people, was top-down, and failed to understand diversity”.Instead, his book points towards a future welfare state that is “financially and environmentally sustainable”, that is “participatory”, where “social rights and needs guide economic policy”, and in which “supporting each other is recognised as a productive creator of real wealth, personal and collective well-being”.If this is to be achieved, he says, the disabled people’s movement has to highlight “not only the bad things that are happening now but the good things it has to offer, and show non-disabled people what disabled people can offer in a much more systematic way”.He also wants to see user-led organisations build more alliances.“We have got to be outward-looking as movements, we have got to collaborate more, we have got to be more tolerant of each other’s differences, we have got to really work on addressing diversity in our activities.”But he feels “optimistic” for the future, as long as disabled people and their organisations work “in concert” with others.“People listen to people with shared understanding and experience, people like them,” he says. “We must show that commonality.”He is convinced that the values represented by the disabled people’s movement and user-led organisations will win through.The values that he says have been imposed on society – individualism, fighting each other, greed and criminality – “seem immensely powerful, but they don’t stand up to investigation”.Instead, what ordinary people want are “traditional values about treating people with respect and not discriminating”.“They are the things that the disabled people’s movement, the other movements and user-led organisations are fighting for,” he says. “They are eternal values and those values will out.”
–shares April 1, 2002 With all the home office workers, laptops are in frequent use. Many times the security prevention in a laptop is turned off when remotely connecting. This is another major internal vulnerability or internal threat.So if 80 percent of IT crimes are internal, what should a company do about it?Perform a security audit, or have one performed.Unless the knowledge, experience and manpower exist in-house, consult an outside expert on audits, policies, and the subsequent security monitoring and prevention service.Ensure adequate background checks on employees.Establish a security policy, and enforce it. This includes implementing things like swipe cards, changing passwords often and restricting sensitive areas. This creates the right attitude toward information security in your company and clarifies the consequences of any found internal breach. A professional consulting firm specializing in policy development can save time and money and ensure an up-to-date policy.Use firewalls. Firewalls protect against unauthorized logins usually from the outside world, preventing hackers from logging on to your network.Use virus scanning software. Attachments to e-mails received and passed around are the biggest reason for the spread of viruses.Implement ongoing managed services.These are only a few ideas for combating internal security threats that surround us all. Enlist the help of a professional security consulting firm that will do both the audit and policy development before implementing a complete managed services package.Michael Bruck is the founding partner of BAI Security, an 8-year-old information security consulting firm. Bruck leads his security team with a successful 16-year background in IT management and senior engineering positions. He is also the developer and author of best practices that are becoming standards in the information security consulting business. He can be reached via www.baisecurity.netor by email at email@example.com.The opinions expressed in this column are those of the author, not of Entrepreneur.com. All answers are intended to be general in nature, without regard to specific geographical areas or circumstances, and should only be relied upon after consulting an appropriate expert, such as an attorney or accountant. Few know as much about your IT security as your employees and former employees do. Here’s how to safeguard your technology from the inside. Technology Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Next Article Security Threats From Within Opinions expressed by Entrepreneur contributors are their own. Q: I have heard that one of the biggest information security threats to a company can come from within. Is this true? What exactly does it mean, and what can be done about it?A: When people think of an information security threat or a “security breach,” thoughts of bad buys, gangsters and hackers come to mind. Companies usually make sizeable investments to prevent intrusions to their systems, put protections in place and know the seriousness of external threats.Companies usually try to patch every loophole and make every system impenetrable. But guess who knows more about these loopholes and ports of penetration than anyone? A company’s own employees (or former employees). In reality, disgruntled, former or fired employees or even external service providers are the most likely culprits of a security breach–anyone with “insider information.” It is for that very reason that four out of five IT-related crimes are committed from within an organization.Internal threats might be someone who knows the weaknesses of the software being used or has the ability to introduce viruses into a system. Viruses can come from within simply by opening e-mail attachments. Some employees find it easy to gain access to restricted areas; this may include the possession of unauthorized passwords. If something is password-protected, chances are there is confidential information involved. Next Step Register Now » Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Add to Queue 3 min read Help prevent internal theft with “Caught in the Act.” Keep your IT under lock and key with Security and Loss Prevention: An Introductionby Philip P. Purpura.
–shares Brian Patrick Eha Report: Snapchat’s 23-Year-Old CEO Said No to $3 Billion From Facebook Next Article 2 min read Technology November 13, 2013 Opinions expressed by Entrepreneur contributors are their own. Add to Queue UPDATE: This Is the 23-Year-Old Entrepreneur Who Just Turned Down $3 Billion From FacebookUntil recently, it would have been a safe bet that no 23-year-old in the world had ever turned up his nose at $3 billion. But that’s exactly what Evan Spiegel, the co-founder and chief executive of messaging service Snapchat, did when Facebook offered to buy his company.Citing unnamed sources familiar with the offer, The Wall Street Journal reports Facebook offered Snapchat an all-cash deal of $3 billion or more. At the time of its last funding round, in June, Snapchat was valued at only $800 million. (It raised $60 million in June of a total $73 million to date.)The deal would have marked Facebook’s most expensive acquisition, outstripping even its $1 billion purchase of Instagram in 2012.Snapchat has been enjoying explosive growth as the app of the moment for teens, tweens and twentysomethings who act like teens. In September, Spiegel announced that his service transmitted 350 million snaps a day, up 75 percent from the time of its $60 million Series B round. Snapchat allows users to send photo and video messages to each other that disappear after several seconds. The ephemeral nature of Snapchats make them a popular medium for sexually suggestive photos, not to mention silly stuff that you don’t want preserved forever on a Facebook Timeline.Still, given that Snapchat has yet to earn any revenue, the idea of turning down a buy offer three times the value of that which Mark Zuckerberg himself once turned down seems — not to put too fine a point on it — insane. It appears Spiegel and his co-founder, Bobby Murphy, also turned down a $200 million investment offer from Chinese company Tencent Holdings that would have valued Snapchat at $4 billion.But Snapchat’s young executives may soon have a better offer on the table. According to The Wall Street Journal, they are hoping their numbers continue to improve through early 2014, when they may be finally willing to consider an acquisition or investment. But they may be kicking themselves if their core user base becomes enamored of another service and leaves Snapchat behind before its founders can cash in.Related: Why Tech Valuations Can’t Be Too High or Too Low 2019 Entrepreneur 360 List The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »
Reviewed by James Ives, M.Psych. (Editor)Feb 12 2019A team of investigators from the Colorado School of Public Health at the CU Anschutz Medical Campus and the University of Colorado Boulder has identified that people living in homes with high ventilation are more likely to suffer from respiratory health issues such as asthma.The findings are published in the February issue of Environmental Research.The Colorado Home Energy Efficiency and Respiratory Health (CHEER) study evaluated the impact of air-exchange rates on respiratory health in low-income, urban homes in the cities of Denver, Aurora, Boulder, Loveland and Fort Collins. The study revealed that many homes had high ventilation rates, also known as air-exchange rates – the rate at which outdoor air replaces indoor air within a room (median 0.54 air changes per hour; range 0.10 to 2.17).The findings show that residents in drafty homes with higher air-exchange rates were more likely to report a chronic cough, asthma and asthma-like symptoms.Notably, people in homes with the highest air-exchange rates were approximately four times more likely to report a chronic cough than people living in households with the lowest air-exchange rates.Similarly, people were two to four times more likely to report asthma or asthma-like symptoms if they lived in households with the highest ventilation rates versus the lowest.”The goal of this study was to understand the health impacts of home weatherization practices. Many of these practices focus on reducing air exchange rates between the building interior and outdoor environment,” said Elizabeth Carlton, PhD, assistant professor in Environmental and Occupational Health at the Colorado School of Public Health. “We found people in the homes with the highest air-exchange rates – the leakiest homes – were considerably more likely to report chronic cough, asthma or asthma-like symptoms. It is possible that in homes with high air-exchange rates, outdoor pollutants are entering the home and affecting health. If true, home-energy efficiency measures may be an effective way to protect health in areas with high pollution such as homes located near major roads.”Related StoriesResearchers study the role of nasal ecosystem and viral infection on pneumococcal acquisitionNew mobile phone application can measure impaired breathingMore than 936 million people have sleep apnea, ResMed-led analysis revealsCarlton adds, “The health effects of high-exchange rates in urban areas are not well-documented, and since Americans spend approximately 90 percent of their time indoors, it’s crucial to have a better understanding of the impact of leaky homes.”While prior studies have highlighted the potential hazards of low ventilation rates in residences, this study reveals high ventilation rates in many urban-area homes and that these high air-exchange rates may have a negative impact on respiratory health. Based on the findings, the infiltration of outdoor pollutants into leaky homes, such as traffic-related pollutants, could be a significant cause of chronic respiratory issues and an array of health outcomes.The (CHEER) research is a cross-sectional study that enrolled 302 people in 216 non-smoking, low-income homes. A blower door test was conducted and the annual average air-exchange rate (AAER) was estimated for each house. Respiratory health was assessed using a structured questionnaire based on standard instruments. The researchers evaluated the association between AAER and respiratory symptoms, adjusting for relevant variants such as age, sex, location and both indoor and outdoor pollution.”This study was a one-of-a-kind opportunity to combine engineering, geography and public health expertise,” said Shelly Miller, PhD, professor in Mechanical Engineering at the University of Colorado Boulder. “We hope that the results of our research will help rethink how we expend energy in homes for heating and cooling and how we best ventilate homes, especially in under-resourced communities that often live in polluted urban areas.” Source:http://www.ucdenver.edu/
Reviewed by Kate Anderton, B.Sc. (Editor)Apr 17 2019A new study led by a research team from Massachusetts Eye and Ear and Harvard Medical School describes how bacteria adapted to the modern hospital environment and repeatedly cause antibiotic-resistant bloodstream infections. Infections acquired by hospitalized patients are more often antibiotic-resistant than those that occur elsewhere, and hospitals invest considerable effort to prevent them. Despite best efforts, some bacteria are able to persist and circulate among patients, causing repeated infections. This study examined one of the first sustained hospital outbreaks of a multidrug-resistant bacterium, Enterococcus faecalis, which occurred from the early through the mid-1980s, causing over 60 outbreak strains.The study, published online April 10 in Science Translational Medicine, was led by a research team headed by Michael Gilmore, PhD, Senior Scientist at Mass. Eye and Ear, and the Sir William Osler Professor of Ophthalmology, and Director of the Infectious Disease Institute in the Department of Ophthalmology at Harvard Medical School. The team compared the DNA sequences of bacteria that had been archived from the outbreak 30 years ago by collaborator Mark M. Huycke, MD, infectious disease specialist now at the University of Oklahoma Health Sciences Center. Spearheaded by Gilmore laboratory research associate Daria Van Tyne, PhD, and with the help of Broad Institute Scientist Ashlee Earl, PhD, the researchers identified mutations in the bacteria as they caused one infection after another over 4 years.The study’s authors hope the novel findings on how enterococci infect the bloodstream will help scientists and physicians develop new ways to prevent these infections from happening, and to better treat them when they occur.”Knowing how the microbes outsmarted the body’s immune system and antibiotics tells us what is critical to the microbe in order to cause infection,” says Dr. Gilmore. “This in turn gives us a clearer shot at new targets for developing the next generation of antibiotics, and for guiding their careful use inside and outside of hospitals.”Naturally occurring in the human gut, enterococci bacteria can lead to infections including bloodstream and urinary tract infections, infections of surgical sites, and endocarditis–infection of the heart valves.Researchers examined the genomes of the bacteria to analyze samples from an early outbreak of bacteremia in patients in a Wisconsin hospital between 1984 and 1988 that was caused by multidrug-resistant Enterococcus faecalis in order to learn how they adapted to existence in the hospital and transmission from one patient to another. By going back to the early days of the antibiotic resistance problem, Dr. Van Tyne, Dr. Gilmore, and colleagues were able to see that Enterococcus faecalis entering into the bloodstream first turn on an unusual pathway that allows the microbe to make a new substance that helps to shore up its cell wall. This makes the bacterium more able to resist being killed by white blood cells, and also by antibiotics of the penicillin class that attack the bacterial cell wall. The authors also saw that in the middle of the outbreak, the types of adaptations suddenly changed, and the bacteria began to reinforce their cell walls in a new way. This change corresponded to the introduction and widespread use of a then-new antibiotic, called imipenem.Related Stories’Scissors’ component of CRISPR/Cas9 sometimes gets stuckStructure of bacteria responsible for traveler’s diarrhea decipheredGrowth problems in preterm infants associated with altered gut bacteriaDr. Van Tyne, now an Assistant Professor in the University of Pittsburgh Department of Medicine, was able to repeatedly recreate the exact change 30 years later in the laboratory, using an imipenem class antibiotic, proving the link.”Our study shows how an enterococcal outbreak lineage emerged and evolved over an extended hospital outbreak and how outbreak strains responded to host immune selection and changing antibiotic regimens,” says Dr. Van Tyne. “These findings highlight new pathways that could be further leveraged in the future for control and management of hospital-acquired enterococcal infections.”Antibiotic resistant infection is a leading threat to public health worldwide. It has been estimated that by 2050, more people could die from infections that are no longer treatable with antibiotics, than from cancer. Understanding how some bacteria have been able to overcome our natural immune defenses, and new drugs as they are introduced, is the key to preventing a future where up to 10 million people could die each year from antibiotic resistant infection, according to Dr. Gilmore.”This research study is a powerful example of how scientists like Dr. Gilmore are utilizing new genetic technologies and molecular biology to uncover new and important information about drug-resistant bacteria, so we may better understand, and ultimately prevent and treat life-threatening infections,” says Joan W. Miller, MD, the David Glendenning Cogan Professor and Chair of Ophthalmology at Harvard Medical School, Chief of Ophthalmology at Mass. Eye and Ear and Massachusetts General Hospital, and Ophthalmologist-in-Chief at Brigham and Women’s Hospital.Source: https://www.masseyeandear.org/news/press-releases/2019/04/genomic-study-identifies-pathway
Professor Elborn’s main focus is Cystic Fibrosis focused on understanding pathophysiology of infection and inflammation and the translation of new therapies into clinical practice. This programme of work is undertaken with laboratory and clinical collaborators in Queen’s University Belfast. This includes a significant commitment from the NICRN (Respiratory Health) where Stuart is PI on 6 current clinical trials. Prof. Elborn has smaller programmes with others in COPD, bronchiectasis, lung cancer including clinical trials. His research is funded by grants from government agencies, charitable bodies, industry and money raised from clinical trials. Professor Elborn has developed a clinical trials network for Respiratory Health funded by the Northern Ireland Research and Development Office.In all his research, Professor Elborn endeavours to bring scientists and clinicians together to promote inter-disciplinary research. I have been successful in developing programmes of research across disciplines, hospitals and universities in Northern Ireland and across the UK and Europe.About Dr Graham Dixon About Prof. Stuart Elborn Sponsored Content by Neem BiotechJun 25 2019 Stuart Elborn & Graham DixonSchool of MDBS Faculty Pro-Vice-Chancellor,Queens University Belfast& CEO, Neem BiotechAn interview with, Professor Elborn and Dr. Dixon, discussing the issues surrounding bacterial respiratory infections associated with chronic lung conditions such as cystic fibrosis, conducted by Alina Shrourou, BSc. How much of a problem are respiratory infections in chronic conditions such as cystic fibrosis, bronchiectasis and COPD?In cystic fibrosis, COPD and people with bronchiectasis, there is a chronic infection that we know now is quite complex and is made up of communities of different species of microbiota; not just bacteria, but also fungi and viruses.© Kateryna Kon/Shutterstock.comIt is possible for patients to have a long-term respiratory infection, causing intermittent episodes of exacerbation where their symptoms increase, often on a background or baseline of continuous symptoms but they flare up and get worse – we call these exacerbations.These events are very strongly related to quality of life and prognosis, so the events themselves reduce quality of life but we also know that frequent exacerbations across a range of respiratory conditions are associated with reduced survival. These events are a bit like a heart attack to the lungs. They do damage, which is irreparable and that probably drives the further reduction in lung function and the reduction in survival.What are the biggest challenges currently associated with treating bacterial infections in patients with chronic respiratory conditions?The main challenges are involved with finding long term treatment that would prevent exacerbations and flare ups. When these events do occur, it is difficult to determine what is the right drug, duration of treatments and context in which to treat these events.We have a number of treatments which we provide long term, but most of these are in cystic fibrosis and are based on inhaled antibiotic therapy. However, many of the antibiotics that are currently licensed, are only licensed for alternate month treatment, so we end up with complex regimes where patients are given two or potentially three types of inhaled antibiotics but they’re rotating those each month.We don’t really know which combinations are most efficacious, and so we are driven by trying to make decisions for individual patients based on very limited evidence.There is some anticipation that good anti-inflammatory therapy might help in this context, but there are no large-scale studies to help us understand that. We have a relatively limited repertoire of antimicrobial therapies which we know can be effective. Then understanding how we use antibiotics or antibiotics agents in a more effective way to prevent these episodes, is equally important.We are also still trying to understand how long we should be giving patients antibiotics for, to treat these exacerbations and to restore the inflammation homeostasis in their lungs. However, we are limited by the drugs available and by the approach that we use, which has developed historically and usually involves a 14-day course of IV antibiotics. There are several studies trying to tackle some of these issues. There’s a program called ‘Stop’, in the US, which is testing the hypothesis that in some patients, a shorter time than 14 days might be just as effective as 14 days of treatment, and some individuals may need longer than 14 days – they may need 21 days for example. There is a large pragmatic clinical trial in North America currently running to try to address those issues.Please outline the work you are involved in at Queen’s University Belfast to help overcome these challenges.We’re running a number of translational clinical trials that are trying to address these issues. The Framework 7 funded a program called CF Matters, using next generation sequencing to determine the bacteria in people with CF. That information was then used to decide in a consensus panel, what additional drugs might be added to the usual IV antibiotics. Although that study is now complete, unfortunately we were not able to demonstrate that the direct therapy based on molecular biome data benefited patients. However, we’re still doing some sub-group analysis because it may be that in some patients, there is in fact benefit from an additional drug.We’re also exploring a number of new antibiotic agents in both CF and bronchiectasis; some of which are conventional antibiotics but, others are of a different approach. We’re trying to re-think how we use current antibiotics, attempting to develop some new antibiotics with collaborators in the pharmaceutical industry and looking at new tools to help determine which antibiotics are most effective in individual patients.What is the importance of AMR resistance and therapy and the need for circumventing AMR in CF and respiratory disorders?This is a particularly tricky issue. We know that antimicrobial resistance (AMR) develops in people with cystic fibrosis who receive antibiotics. For example, resistance to Pseudomonas aeruginosa increases in individuals with CF, with age and antibiotic exposure. Usually the first infection of Pseudomonas is with a very antibiotic sensitive organism. However, through intrinsic mutations over time, the bacteria develop a resistance profile. It is also possible to cross infect with a resistant Pseudomonas so some patients may acquire a resistant pseudomonas from other patients if there aren’t effective infection control procedures in place.We know that resistance occurs in cystic fibrosis, so what is left to determine, is whether resistance predicts response to treatment. In inhaled antibiotic studies, and in a number of studies looking at this for treatment of exacerbations, there isn’t a strong relationship between resistance and successful treatments and this is very much in contrast to treatments of acute infections where resistance is a very good predictor of outcome in, for example, infection or sepsis associated with neutropenia. We are dealing with a different context of chronic infections associated with exacerbations.Related StoriesWound healing work presented at the RCP Innovation in Medicine Conference 2018 by Neem BiotechExperts drive Neem Biotech’s efforts to counter effects of antimicrobial resistance on treatment of lung infectionsAward granted to Neem Biotech to develop antimicrobial intervention for chronic lung infectionsIt’s not as straight forward as acute infection but we need new and prospective therapies that will circumvent the antimicrobial resistance nature of chronic infections in cystic fibrosis and other chronic lung diseases, and/or use mechanisms that are not genetically determined, providing therapies that would be consistently effective in people with chronic lung infection.What makes Neem Biotech’s approach to respiratory infections unique?Neem are coming at it from a non-traditional antibiotic angle involving novel mechanisms of action.Quorum sensing describes a way in which bacteria communicate, and it drives the production of various factors which allows them to infect and damage tissue. By blocking quorum sensing, it means that the bacteria cannot produce biofilms which then become chronic infections and are very protected both from antibiotics and the host immune system. By approaching this system, we are investigating the possibility of stopping the bacteria from becoming invasive, rather than killing the bacteria per se, as resistance development can be slowed with reduced pressure on the bacteria to reproduce.Disrupting communication between microbes is likely to make them more amenable to clearance by normal immune pathways and make the microbes more susceptible to antibiotic killing.We’re excited about this program, because we’re taking the understanding of the biology of bacterial host interaction and translating the science through to the therapies that will work with the immune system to improve outcomes in this condition.Are there ways in which higher education, industry, health authorities and clinical practitioners can work together more effectively to prove the value and cost benefit of innovations in the field of chronic respiratory infections?Yes, there are a wide range of initiatives; some of which are generic to healthcare and the use of antibiotics, but there are some specific programs which are now developing in CF.A couple of years ago, we were able to persuade the CF community in North America, Europe and Australasia to put together a working group that would address key questions around the medical need and assess the evidence around how we currently use antibiotics in people with cystic fibrosis. The outputs of that are in the process of being published.The outputs identify some of the challenges in identification and laboratory determination of infection; through to what we know, or perhaps more importantly, what we don’t know, where the gaps are, and scoping what other future steps we need to take in terms of development of new drugs and how we use the learning from antimicrobial stewardship to improve long term outcomes in people with CF.We’ll be developing some education programs over the next 12 – 24 months that we’ll be able to use to help educate healthcare teams looking after people with CF, and for cystic fibrosis patients themselves. We’ve just finished a large survey in both of those sectors to gauge the understanding of these issues so that we can really target the right education to our community. I think that the lack of cystic fibrosis educational materials is huge issue for us as a society and in CF. We need to make a contribution to that by understanding the problem, having the right therapies and the right program of treatment and understanding how antimicrobial stewardship might be really important in long term outcomes for our patients.Neem are contributing to this initiative by participating in a syndicate that’s run by the UK Cystic Fibrosis Trust. It involves academia, the pharmaceutical industry and the Cystic Fibrosis Trust, and it looks at how those groups can work together to improve success in R&D and cystic fibrosis. One of the elements we are involved in is investigating how we develop better, more predictable and translatable models in vitro, ex vivo and in vivo to evaluate potential new cystic fibrosis drugs.We also have the newly formed Respiratory Innovation Wales – a group that brings together academia, industry and the NHS to try and research respiratory conditions more generally, with an aim of better facilitating the movement of drugs through the system.What would interdisciplinary respiratory research success look like in the future?Working together is key. Taking good science from academia and developing that within an industrial environment, being able to link to medical professionals and make that translational leap. I believe there is also value in approaching the NHS to facilitate the clinical development and clinical trials programs. It’s really a very collaborative effort and that’s why the Respiratory Innovation Wales has been set up to try and help with. Then naturally, that leads to patient inclusion.How do you expect the success of Neem’s research to impact the existing knowledge base and clinical practice in management of bacterial infections in chronic respiratory conditions?The introduction of a new class of antibiotic that has a novel mechanism would be a terrific additional therapeutic opportunity in CF and other chronic lung conditions. To be able to modulate the pathogenicity of a bacterium without having a severe impact on the good bacteria that sits in the lung, could really start to move people with devastating diseases such as CF back to have lungs with a much healthier ecosystem and associated with improved health and further increases in survival.Where can readers find more information? www.neembiotech.com UK Cystic Fibrosis Trust – www.cysticfibrosis.org.uk British Lung Foundation – www.blf.org.uk/support-for-you Dr Graham Dixon obtained his PhD in biochemistry at Swansea University and has spent over 25 years in Big Pharma, VC funded and publicly listed biotechnology companies. As Chief Scientific Officer and later Chief Executive Officer he has led over ten positive proof of concept programmes in humans and been a part of several new drug approval programmes in biotechnology companies including Neem Biotech, Onxeo, Sensorion, Addex Therapeutics, Galapagos, Entomed and F2G.Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.
© 2018 The Associated Press. All rights reserved. In this Wednesday, Feb. 21, 2018, photo, the camera lens of a Samsung Galaxy S9 mobile phone is shown in this photo during a product preview in New York. Though Samsung already has one of the best smartphone cameras, it is looking to produce even better low-light shots, while offering a video mode that appears to freeze fast-moving objects. (AP Photo/Richard Drew) Some of the increases will be offset with promotions. And T-Mobile will cut prices from last year’s models. You can also buy unlocked versions more cheaply directly from Samsung—$720 for the S9 and $840 for the S9 Plus—though most people in the U.S. buy through their carriers.The new phones were unveiled Sunday in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. Citation: New Samsung phone: Nicer camera, static design, higher price (2018, February 26) retrieved 18 July 2019 from https://phys.org/news/2018-02-samsung-nicer-camera-static-higher.html For the first time in a major phone, the S9 will let you change the camera’s aperture to let in more light, making for better images in dark settings.But analyst Carolina Milanesi of Creative Strategies warns that despite the improvements, the new camera is competing with already good cameras in earlier Samsung phones.Nonetheless, you may have to pay more, though nothing quite at the level of last year’s $100 price hikes for the Galaxy S8. In the U.S., Verizon, AT&T and Sprint are raising prices from what the S8 cost at launch—to nearly $800 for the regular-size S9 and more than $900 for the larger S9 Plus. As people hold onto phones longer before upgrading, price hikes let manufacturers and carriers make up for lost revenue. This Wednesday, Feb. 21, 2018, photo shows the Samsung Galaxy S9 Plus, left, and back of a Galaxy S9 mobile phone, during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) Explore further — UNCHANGED: The S9 features the same screen, same virtual home button and same battery capacity as the S8. Samsung did move the fingerprint sensor on the back to reduce smears on the camera lens.— A SECOND LENS: The camera on the Plus model now has a second lens with twice the magnification, a feature already available in Samsung’s Galaxy Note 8 and some iPhones. This means sharper close-ups.— FUN WITH SELFIES: Snap a selfie, and Samsung’s software will turn that into an emoji version of you for sharing. It’s usually a static image, though you can produce an animated version—much like the iPhone X’s Animoji feature.— VISUAL ASSISTANT: Samsung’s Bixby digital assistant mimics a similar Google feature that pulls up information on landmarks or other items you’ve just photographed. New Bixby capabilities let it instantly translate signs (point the camera, and the phone replaces the sign’s text in a matching color and font) and provide nutritional info for that restaurant meal you’re splurging on. Here are some additional things to know: Samsung unveiled new smartphones with largely unchanged designs and incremental improvements such as a better camera—accompanied by a second annual price increase for many customers. In this Feb. 21, 2018, photo, the Bixby virtual assistant software of a Samsung Galaxy S9 Plus mobile phone translates a foreign language sign during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) This Wednesday, Feb. 21, 2018, photo shows an Apple iPhone X, left, and a Samsung Galaxy S9 Plus mobile phone during a preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) Mark your calendars: Samsung preps for Galaxy S9 launch This Wednesday, Feb. 21, 2018, photo shows an Apple iPhone X, left, and a Samsung Galaxy S9 Plus mobile phone during a preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) In this Feb. 21, 2018, photo, the Bixby virtual assistant software of a Samsung Galaxy S9 Plus mobile phone translates a foreign language sign during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) This Wednesday, Feb. 21, 2018, photo shows the Samsung Galaxy S9 Plus, left, and Galaxy S9 mobile phones are shown in this photo during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) In this Wednesday, Feb. 21, 2018, photo the Bixby virtual assistant software of a Samsung Galaxy S9 Plus mobile phone identifies food and displays its calorie content during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) The static design of the new Galaxy S9 underscores both the slowing pace of smartphone innovation and the extent to which other manufacturers, particularly Apple, have caught up with Samsung features that once stood out. That includes everything from edge-to-edge screens to facial recognition to a water-resistant body.The new phone’s biggest selling point is a collection of minor improvements to its camera, which is already among the best in the smartphone business . The S9 promises even better low-light shots, while offering a video mode that appears to freeze fast-moving objects, matching a feature in some Sony phones. The S9 can automatically detect when there’s high-speed motion to record, such as a cork popping off a bottle of champagne. A fifth of a second of video gets stretched out into six seconds.While single features like this aren’t likely to drive buying decisions, the slow-motion effect could be “the kind of thing that will get a lot of attention,” said Bob O’Donnell of the research firm Technalysis. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. This Wednesday Feb, 21, 2018, photo shows the camera lens of a Samsung Galaxy S9 mobile phone during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew) In this Wednesday, Feb. 21, 2018, photo, Samsung’s Aaron Baker demonstrates the AR Emoji feature on a Samsung Galaxy S9 Plus mobile phone during a product preview in New York. The Galaxy S9 phones were unveiled Sunday, Feb. 25, in Barcelona, Spain, and will be available March 16. Advance orders begin this Friday. (AP Photo/Richard Drew)
What does it take to be a space archaeologist? No, you don’t need a rocket or a spacesuit. However, lasers are sometimes involved. And infrared cameras. And spy satellites. Welcome to Sarah Parcak’s world. Parcak, an archaeologist and a professor of anthropology at the University of Alabama at Birmingham, has mapped sites around the world from space; she does so using images captured by satellites — from NASA and from private companies — orbiting high above the ground. From these lofty heights, sensitive instruments can reveal details that are invisible to scientists on the ground, marking the positions of walls or even entire cities that have been buried for millennia. Parcak unpacks how views from space are transforming the field of archaeology, in her new book “Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019). [Read an excerpt from “Archaeology From Space”] AdvertisementArchaeology Gets a Sci-Fi Makeover, In ‘Archaeology From Space’Live Science sits down with archaeologist and author Sarah Parcak to talk about her new book, “”Archaeology From Space: How the Future Shapes Our Past” (Henry Holt and Co., 2019).Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Fomalhaut Stars Huge Ring of Dusty Debris Captured by ALMA | Video00:54关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65924-space-archaeology-highlights.html?jwsource=cl已复制直播00:0020:0420:04Your Recommended Playlist00:54Fomalhaut Stars Huge Ring of Dusty Debris Captured by ALMA | Video00:43OTD in Space – July 16: Apollo 11 Launches to the Moon13:13Apollo 11 Astronaut Michael Collins Talks Launch on 50th Anniversary06:26How To Find Jupiter and Other Skywatching Objects in July 2016 | Video02:22Skywatching Planets and the Harvest Moon In September 2014 | Video02:22Space.com Builds: Lego NASA Apollo Saturn V Rocket关闭 Satellites analyze landscapes and use different parts of the light spectrum to uncover buried remnants of ancient civilizations. But studying archaeological sites from above had very humble (and low-tech) beginnings, Parcak told Live Science. Researchers first experimented with peering down from a great height at a historic location more than a century ago, when a member of the Corps of Royal Engineers photographed the 5,000-year-old monument Stonehenge from a hot-air balloon. “You could even see — from this very early and somewhat blurry photograph — staining in the landscape around the site, showing that there were buried features there,” Parcak said. Through the 1960s and into the 1970s, aerial photography continued to play an important role in archaeology. But when NASA launched its first satellites it opened up “a completely new world,” for archaeologists in the 1980s and 1990s, Parcak said. In fact, declassified images from the U.S. government’s Corona spy satellite program, which operated from 1959 to 1972, helped archaeologists in the 1990s to reconstruct the positions of important sites in the Middle East that had since disappeared, eradicated by urban expansion. An eye inlay from a tomb dating to 4,000 years ago, in Lisht, Egypt. The expedition, co-led by Dr. Parcak, was conducted in partnership with the Egyptian Ministry of Antiquities. Credit: Courtesy of Sarah Parcak Today, aerial or satellite images captured by optical lenses, thermal cameras, infrared and lidar — light detection and ranging, a type of laser system — are well-established as part of an archaeologist’s tool kit. And archaeologists need as many tools as they can get; there are thought to be millions of sites around the world that are yet to be discovered, Parcak added. But remote sensing isn’t one-size-fits-all; different terrains require different space archaeology techniques. For example, in Egypt, layers of sand blanket lost pyramids and cities. In that type of landscape, high-resolution optical satellites reveal subtle differences on the surface that may hint at structures underground. And in regions with dense vegetation, such as in Southeast Asia or Central America, lidar emits millions of pulses of light to penetrate beneath the trees and detect hidden buildings, Parcak explained. In her own work, Parcak’s analysis of satellite views led to the creation of a new map for the legendary city of Tanis in Egypt, famously featured in the movie “Raiders of the Lost Ark.” Satellite images of Tanis revealed a vast network of the city’s buildings, which had previously gone undetected even as the site was under excavation, she wrote. Image Gallery: How Technology Reveals Hidden Art Treasures In Photos: Ancient Egyptian Tombs Decorated with Creatures 7 Amazing Places to Visit with Google Street View If these stories of space archaeology in Parcak’s book leave readers wanting more, they’re in luck. An online platform called GlobalXplorer, launched and run by Parcak, offers users access to a library of satellite images for browsing and annotation. Aspiring “citizen-scientists” can join “campaigns” to assist in the ongoing search for lost cities and ancient structures, and to help experts identify signs of looting in vulnerable sites, according to the platform website. Since 2017, approximately 80,000 users have evaluated 14 million satellite images, mapping 700 major archaeological sites that were previously unknown, Parcak said. “Archaeology From Space” is available to buy on Amazon. Satellite images of the buried ancient Egyptian city Tanis revealed city walls that were invisible to archaeologists on the ground. Credit: Courtesy of Sarah Parcak Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndo
Will the Supreme Court strike down Article 377? (file photo) Published on Once criminality of Article 377 goes, stigma against LGBTQ also will: SC SC to hear pleas challenging re-criminalisation of homosexuality, refuses to adjournments SHARE COMMENTS COMMENT SHARE SHARE EMAIL The courts cannot wait for a “majoritarian government” to decide on enacting, amending or striking down a law if it violates fundamental rights, the Supreme Court asserted today. “We would not wait for the majoritarian government to enact, amend or not to enact any law to deal with violations of fundamental rights,” a five-judge bench headed by Chief Justice Dipak Misra observed while hearing a batch of petitions seeking decriminalisation of consensual gay sex. The courts are not in obligation to wait and would act if any violation of fundamental right was brought before it, the bench, which also comprised Justices R F Nariman, A M Khanwilkar, D Y Chandrachud and Indu Malhotra, said. The observations by the bench, which is dealing with a clutch of petitions challenging the constitutional validity of section 377 of the Indian Penal Code, came when advocate Shyam George, appearing for some Apostolic Alliance of Churches and Utkal Christian Association, submitted that it was the legislature’s job to decide whether to amend or allow section 377 in the statute book. “The moment we are convinced about violation of the fundamental right, the object of these fundamental rights give power to the court to strike down the law,” the bench said.The lawyer also referred to the term “sexual orientation” and said it cannot be read interchangeably with the term “sex” used in article 14 and 15 which deal with the right to equality of the citizen. He said the term sexual orientation was different from the term sex as there have been several kinds of sexual orientation, besides the LGBTQ (lesbian, gay, bisexual, transgender and queer).Section 377 refers to ‘unnatural offences’ and says whoever voluntarily has carnal intercourse against the order of nature with any man, woman or animal, shall be punished with imprisonment for life, or with imprisonment of either description for a term which may extend to 10 years, and shall also be liable to pay a fine. The advancing of arguments would resume later in the afternoon.The top court had on July 12 said the social stigma and discrimination attached to the LGBTQ community would go if criminality of consensual gay sex is done away with, while maintaining that it would scrutinise the legal validity of section 377 of the IPC in all its aspects.The court had observed that an environment has been created in the Indian society over the years that has led to deep-rooted discrimination against the community which has also adversely impacted their mental health.Earlier, the government had left it to the apex court to test the constitutional validity of section 377, urging that issues like gay marriages, adoption and ancillary civil rights of LGBTQ should not be dealt by it.Taking note of the Centre’s submission that other issues like gay marriages, adoption and ancillary civil rights of LGBTQ community should not be dealt, the court said it was not considering all these issues.The bench had said it would test the validity of the law in relation to the consensual sexual acts of two adults and if it decides to strike down the penal provision then it would remove “ancillary disqualification” of LGBTQ community members which can join services, contest elections and form associations. Section 377: Centre leaves it to the wisdom of SC to decide validity July 17, 2018 RELATED “We would not wait for the majoritarian government to enact, amend or not to enact any law to deal with violations of fundamental rights.” justice and rights
SHARE May 28, 2019 national politics Published on SHARE SHARE EMAIL COMMENTS West Bengal Crossover artists With the defection of 60-odd councillors, the BJP will now control at least three urban local bodies (municipalities) in the State – Sandeep Saxena COMMENT CPI(M) legislator Devendra Roy, too, switches loyalty The ruling Trinamool Congress (TMC) in West Bengal witnessed its first exodus as two dissenting MLAs and over 60 councillors joined the BJP on Tuesday.This is the first open-attempt by a reinvigorated BJP to break through the TMC ranks here.Prime Minister Narendra Modi, during one of his election rallies in the State, had said that “40 (TMC) MLAs were in touch with the BJP” and that they would switch over, post polls.“The BJP has not taken its foot off the pedal here in Bengal and is using the same game-plan that Banerjee had used to break the CPI(M) and the Congress,” a political analyst said on conditions of anonymity. Those who switched allegiance include suspended TMC MLA and BJP leader Mukul Roy’s son Subhranshu Roy. Others include Tushar Kanti Bhattacharjee and CPI(M)’s Devendra Roy.Subhranshu was amongst the first dissidents of the TMC who spoke out about the party’s poor show in the polls.The switch-over of these 60-odd councillors means the BJP will have control of at least three urban local bodies (municipalities) in the State.“Rats are the first one to flee a sinking ship. But they do not realise that they are jumping into a sea. Leaders are being forced to switch sides,” West Bengal Urban Development Minister, Firhad Hakim, said.The dissidents joined the BJP at the party’s headquarters in Delhi in the presence of Kailash Vijayvargiya, BJP’s national general secretary and party leader Mukul Roy.According to Vijayvargiya, more leaders are in touch and are expected to switch over soon. A selection process has also been put in place.“The joining of these leaders will happen across seven phases,” he said, adding that “several leaders are feeling suffocated in the TMC”. Ahead of the 2019 Lok Sabha polls, some of the TMC dissidents switched sides to join the BJP. At least three of these dissidents won subsequently.A stellar show by the BJP in West Bengal in the just-concluded Lok Sabha polls saw the party snatch at least 12 seats from the ruling TMC. The BJP won 18 seats, while the ruling TMC won 22. The Congress managed two seats. ‘Hunt for traitors’Signs of dissidence among TMC leaders have been on the rise since May 23. On Saturday, Banerjee begun a re-organisation exercise within the party and alleged that “there was internal sabotage”. According to Banerjee, her party has launched a hunt for the “traitor(s)” within as a part of its performance review.Sources said the TMC has identified 192 Assembly segments in the 294-member Assembly as “troubled zones”.On a micro level, the TMC found itself trailing in 129 Assembly segments. There are 60 more seats where the BJP is breathing down its neck. Results here can go either way.Meanwhile, Mamata Banerjee said she will attend Modi’s the swearing-in ceremony. “I have spoken to the other Chief Ministers. We will try and make it to the swearing-in. It is our Constitutional duty,” she said politics